Table 2.

Methodological quality of the 13 RCTs

Study	Random method	Allocation concealment	Blind method	Lost or exit	Quality assessment	Inclusion/exclusion criteria	Outcome measurement
Miele et al[13], 2009	Right	Right	Double blind	Yes, use ITT analysis	A	Both	CAI by Lichtiger; EI score; HI score
Sood et al[12], 2009	Right	Right	Double blind	Yes, use ITT analysis	A	Both	DAI by Sutherland
Henker et al[15], 2008	Right	Non-described	Non-described	No	B	Inclusion criteria	CAI by Rachmilewitz
Zocco et al[20], 2006	Right	Non-described	Non-described	No	B	Both	CAI by Rachmilewitz; EI by Baron; HI by Truelove-Richard
Matthes et al[11], 2006	Right	Not used	Double blind	Yes, use ITT analysis	C	Not mentioned	DAI by Sutherland
Furrie et al[9], 2005	Right	Non-described	Double blind	No	B	Inclusion criteria	CAI by Walmsley; SI by Baron
Tursi et al[8], 2004	Right	Non-described	Non-described	Yes, use ITT analysis	B	Both	CAI by Lennard; EI score; HI score
Kruis et al[18], 2004	Right	Right	Double blind	Yes, use ITT analysis	A	Both	Scores according to Rachmilewitz
Kato et al[10], 2004	Right	Non-described	Non-described	No	B	Both	CAI by Lichtiger; EI by Harig, Scheppach; HI by Matts
Cui et al[16], 2004	Right	Not used	Non-described	No	C	Not mentioned	Not mentioned
Ishikawa et al[17], 2003	Right	Non-described	Non-described	No	B	Inclusion criteria	Exacerbation of clinical symptoms
Rembacken et al[14], 1999	Right	Non-described	Double blind	Yes, use ITT analysis	B	Inclusion criteria	Scores according to Rachmilewitz
Kruis et al[19], 1997	Right	Non-described	Double blind	Yes, use ITT analysis	B	Both	The same of the CAI score under the E. coli and mesalazine; Scores according to Rachmilewitz

CAI: Clinical activity index; SI: Sigmoidoscopy index; EI: Endoscopy; HI: Histology index.