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FIGURE 5.

FIGURE 5.

Alternative models for the “first come, first served” mechanism of splice site selection. (A) Fast elongation promotes usage of the stronger downstream 3′ splice site. (B) Slow elongation causes preferential excision of the upstream intron (first served equals first excised). (C) Slow elongation causes commitment to E33 inclusion via recruitment of splicing factors (first served equals first committed). Both introns are excised individually and in an order that is independent of elongation.