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. 2010 Apr 19;189(2):325–338. doi: 10.1083/jcb.200904114

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© 2010 Yamamizu et al.

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Figure 8. — Molecular mechanisms of arterial EC specification. cAMP signaling, which could be induced by adrenomedullin, shear stress, and so on, activates Notch and β-catenin signaling through PI3K (and GSK3β) in vascular progenitors (as well as differentiating ECs). Notch and β-catenin signaling subsequently converges into a single protein complex with RBP-J, NICD, and β-catenin (arterial complex) on arterial genes. Notch signaling from Notch ligand binding and β-catenin signaling from Wnt and VE-cadherin should also participate in forming the complex. The arterial complex should play a central role in the specification of arterial cell fate in ECs.