Table 2.

Brain Regions	Control		Stroke		Ratio L/R Control	Ratio L/R Stroke
	Left	Right	Left (Ipsi)	Right (Contra)
Accumbens	1.41±0.39	1.53±0.44	1.09±0.44*	1.17±0.32#	0.92 ± 0.04	0.92 ± 0.18
Caudate-Putamen	1.32±0.31	1.37±0.0.34	1.01±0.22*	1.16±0.20#,a	0.97 ± 0.05	0.88± 0.14
Cingulate	2.5±0.3	2.48±0.3	2.36±0.31	2.34±0.34	1.0 ± 0.04	1.01 ± 0.04
Frontal Cortex	2.3±0.27	2.31±0.3	1.98±0.41*	2.07±0.35a	0.99 ± 0.04	0.95± 0.06
Lateral Septum	1.6±0.63	1.63±0.6	1.16±0.26*	1.15±0.28*	0.98 ± 0.09	1.02 ± 0.12
Medial Preoptic Area	0.67±0.19	0.59±0.2	0.48±0.25	0.49±0.26	1.2 ± 0.24	0.98 ± 0.23
Parietal Cortex	2.38±0.28	2.42±0.3	1.89±0.50*	2.07±0.3#,a	0.99 ± 0.09	0.91 ± 0.13
Piriform Cortex	1.55±0.15	1.55±0.2	1.38±0.40	1.43±0.38	1.0 ± 0.12	0.96 ± 0.08
Substantia Innominata	0.9±0.3	0.85±0.4	0.5±0.23*	0.51±0.27*	1.2 ± 0.6	1.02 ± 0.3
Ventral Pallidum	0.98±0.4	0.98±0.4	0.68±0.36#	0.63±0.33*	1.03 ± 0.24	1.13 ± 0.3

Effect of MCAO on regional specific binding of [³H] MK801 to NMDA receptors

Results are Mean ± SD of [³H]MK801 specific binding, expressed in cpm/mm², measured in 9 control and 17 MCAO animals killed 2 weeks (N=4) or 30–40 days (N=13) after occlusion. Non-specific binding assessed in the presence of excess unlabeled MK801 was subtracted from all measurements. Values from regions involved in MCAO-related infarction are in bold. Left = Left hemisphere, Right = Right Hemisphere, Ipsi = ipsilateral to lesion, Contra = Contralateral, L/R=ratio of left hemisphere value to right hemisphere value. A three way ANOVA revealed highly significant effects of region and surgery (p<0.0001) but no effect of side and no region x side interaction. . Subsequent post hoc analyses were performed using Fisher’s PLSD test and paired t-test.

^*p<0.05 compared to control.

^#0.05<p<0.1 compared to control

^ap<0.05 compared to ipsilateral hemisphere by paired t-test.