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. Author manuscript; available in PMC: 2010 Apr 20.
Published in final edited form as: J Neurovirol. 2009 Apr;15(2):164–175. doi: 10.1080/13550280902755375

Figure 5.

Figure 5

Effects of cocaine and/or gp120 on mitochondria membrane potential in rat neurons. (A) Cells treated with cocaine and/or gp120 for 18 h were assayed for mitochondrial membrane potential by staining with JC-1 dye. Cotreatment of cells with cocaine and/or gp120 exposure resulted in reduction of the aggregation of JC-1 dye in the mitochondria (red fluorescence) and decreased ratio of the aggregate (red fluorescence) to monomer JC-1 (green fluorescence) in the cells. (B) Quantification of Δ ψm expressed as a ratio of J-aggregate to JC-1 monomer (red:green) fluorescence intensity using fluorescence plate reader. *P<.05; **P<.01 versus control group; ##P<0.01 versus gp120 group; ^^P<0.01 versus cocaine group.