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. 2010 Feb 10;285(15):11033–11038. doi: 10.1074/jbc.R109.075044

FIGURE 1.

FIGURE 1.

Strategies to modulate transcriptional activation. 1, interference of the endogenous activator DBD-DNA interaction using non-natural DBD mimics to inhibit transcriptional activation. 2, interference of the endogenous activator TAD-coactivator interaction using TAD mimics to inhibit transcription. TAD mimics can also be used to block activator TAD-masking protein interactions, thus stimulating transcriptional activation. 3, reconstitution of activator function using ATFs consisting of a non-natural TAD localized to the gene of interest using a DBD. Med, Mediator; RNA Pol II, RNA polymerase II.