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Small molecule transcriptional activator TAD mimics and NR inhibitors. A, p53 TAD mimic shown to inhibit p53-MDM2 interaction; B, TAD-CH1 domain (CBP/p300) inhibitors; C, TAD-KIX domain (CBP/p300) inhibitors; D, ESX mimics; E, inhibitors of thyroid receptors (L3) and ARs (23).
