FIGURE 1.

Histones and their PTMs. A, mononucleosome structure with histone tails protruding from the core. This figure was generated from Protein Data Bank code 1KX5 with PyMOL. The colors used for individual histones are the same as described for B. B, schematic representation of histone tails and their modifications. Some modifications at the histone C terminus and globular core are also shown. Groups are indicated as follows: ac, acetyl; Cit, citrullyl; me, methyl; ph, phosphoryl; pr, propionyl; rib, ADP-ribosyl; and Ub, ubiquityl. This figure was adapted from Ref. 49.