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hSERT C109A/G338C/Y95F exhibits partial restoration of 5-HT uptake. hSERT C109A, C109A/G338C, and C109A/G338C/Y95F mutant cDNAs were transiently transfected in HEK-293T cells at equal concentrations and assayed for uptake at a single [3H]5-HT concentration (see “Experimental Procedures”). Results represent the means ± S.E. from three experiments. Means of mutant uptake were compared with C109A using two-way Student's t test, with the asterisks indicating p < 0.001.
