FIGURE 4.

DXMS reveals regions of disorder in Msh2-Msh6. A, percentage deuterium incorporation (y axis) is displayed for individual peptides of Msh2-Msh6 after 30 s (black bars) or 300 s (green bars) that span the indicated sequence on the x axis. Regions containing peptides that fully exchange rapidly or do not exchange at all are boxed. B, regions containing extremely rapidly (red) and slowly (blue) exchanging peptides are mapped onto the structure of the Msh2-Msh6 heterodimer. C, regions 8–9 and 19–23 are mapped onto a ribbon diagram of the ATPase domain.