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. 2010 Feb 25;285(17):13012–13021. doi: 10.1074/jbc.M109.037747

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — Hypothetical model of action of AIRE-DAXX interaction. The figure shows the proposed working model, which is summarized as follows. A, AIRE-PHD1 binds H3K4me0 and recruits H3K4 histone methyltransferase, which establishes the H3K4me3 mark, characteristic of a transcriptional active chromatin state. B and C, complex DAXX-HDAC-H3K4HDM represses AIRE activity by the simultaneous event of histone deacetylation and Lys-4 demethylation. Subsequently epigenetic repression markers as H3K4me0, H3K27me3, and deacetylation occur. D, complex DAXX-HDAC-H3K4HDM is removed, and AIRE inhibits H3K27 histone methyltransferase. The positive epigenetic markers such as H3K27me0, H3K4me3, and acetylation take place.