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. 2010 May;2(5):a001032. doi: 10.1101/cshperspect.a001032

Figure 2.

Figure 2.

Individuals with different genotypes of MDM2 SNP309 could be affected differently by estrogen signaling manipulation. A model has been proposed that the primarily female-specific hormone, estrogen, preferentially stimulated transcription of the MDM2 gene with the G-allele of SNP309, potentially through the direct interaction of the estrogen receptor (ESR) and the transcription factor SP1 on the MDM2 promoter. If true, this predicts that inhibition of estrogen signaling in individuals with the G-allele of MDM2 SNP309 would lead to a reduction of MDM2 levels and a reactivation of p53 activity, allowing for either better tumor suppression or tumor clearance compared with individuals with the T-allele.