Table 3.

Univariate and multivariate associations for 188 males with ischaemic heart disease compared with 485 age matched controls without ischaemic heart disease

	Unadjusted			Adjusted
	Odds ratio (95% CI)	P value		Odds ratio (95% CI)*	P value
First diagnosis of anxiety or depression before diagnosis of heart disease
Depression†	3.09 (1.33 to 7.21)	0.009		2.75 (1.13 to 6.69)	0.03
Anxiety‡	1.62 (0.46 to 5.63)	0.45		1.40 (0.37 to 5.25)	0.62
Duration of depression (years)§:
⩽10	3.13 (1.27 to 7.70)	0.01		3.12 (1.23 to 7.93)	0.02
>10	2.18 (0.61 to 7.77)	0.23		1.63 (0.41 to 6.44)	0.048
Tricyclic antidepressants¶	3.49 (0.95 to 12.85)	0.06		3.55 (0.89 to 14.21)	0.07
Mean daily dose of tricyclic antidepressant¶:
<75 mg	2.92 (0.61 to 13.91)	0.18		2.97 (0.58 to 15.11)	0.19
⩾75 mg	4.71 (0.70 to 31.77)	0.11		5.02 (0.62 to 40.56)	0.13
Duration of tricyclic antidepressants (months)¶:
⩽4	5.07 (0.88 to 29.15)	0.07		5.47 (0.84 to 35.50)	0.08
>4	2.27 (0.36 to 14.50)	0.39		2.19 (0.31 to 15.49)	0.43
First diagnosis of anxiety or depression after diagnosis of heart disease
Depression†	2.20 (1.28 to 3.79)	0.005		2.34 (1.34 to 4.10)	0.003
Anxiety‡	1.61 (0.75 to 3.48)	0.220		1.62 (0.73 to 3.59)	0.23
Tricyclic antidepressants¶	1.83 (1.00 to 3.37)	0.05		1.82 (0.97 to 3.41)	0.06
Selective serotonin reuptake inhibitors**	4.01 (1.41 to 11.44)	0.009		4.68 (1.61 to 13.60)	0.005

^*Model adjusted for smoking status, hypertension, diabetes, and depression score.  

^†Relative to subjects without depression. ^‡Relative to subjects without anxiety. ^§Relative to a baseline of no depression. ^¶Relative to subjects who had not had tricyclic antidepressants. ^**Relative to subjects who had not had selective serotonin reuptake inhibitors.