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. Author manuscript; available in PMC: 2010 Apr 20.
Published in final edited form as: Alcohol Clin Exp Res. 2008 Dec 13;33(3):435–447. doi: 10.1111/j.1530-0277.2008.00854.x

Fig. 2.

Fig. 2

Scopolamine and ethanol synergistically enhance locomotor activity in FAST mice. Shown are Day 3 minus Day 2 drug stimulation scores. Mice were treated with saline or scopolamine followed 10 minutes later by saline or ethanol treatment. Locomotor activity was assessed for 30 minutes following the second injection; n = 23 to 24 female FAST mice/group. (A) Shown are data from the first 5 minutes of the total 30-minute test. #Significant difference between activity levels of 0 mg/kg scopolamine + 1g/kg ethanol and those receiving 0.5 mg/kg scopolamine + 1 g/kg ethanol (p < 0.05). @Significant difference between activity levels of 0 mg/kg scopolamine + 0 g/kg ethanol and those receiving 0 mg/kg scopolamine + 2 g/kg ethanol (p < 0.05). (B) Shown are cumulative data for the 30-minute test. The inset shows the response to the combined 0.5 mg/kg dose of scopolamine and the 1 g/kg dose of ethanol, compared to each dose alone, to illustrate the super-additive effect. *Significant difference between activity levels of 0 mg/kg scopolamine + 0 g/kg ethanol and those receiving 0.5 mg/kg scopolamine + 0 g/kg ethanol (p < 0.05). #Significant difference between activity levels of 0 mg/kg scopolamine + 1 g/kg ethanol and those receiving 0.5 mg/kg scopolamine + 1 g/kg ethanol (p < 0.05). %Significant difference between activity levels of 0 mg/kg scopolamine + 2g/kg ethanol and those receiving 0.25–0.5 mg/kg scopolamine + 2 g/kg ethanol (p < 0.05). @Significant difference between activity levels of 0mg/kg scopolamine + 0 g/kg ethanol and those receiving 0 mg/kg scopolamine + 2 g/kg ethanol (p < 0.05).