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. Author manuscript; available in PMC: 2010 Apr 20.
Published in final edited form as: Alcohol Clin Exp Res. 2008 Dec 13;33(3):435–447. doi: 10.1111/j.1530-0277.2008.00854.x

Fig. 5.

Fig. 5

SCH-23390 has no effect on scopolamine-, ethanol-, or scopolamine + ethanol-induced locomotor activity. Shown are Day 3 minus Day 2 drug stimulation scores. Mice were treated with saline or SCH-23390 followed 15 minutes later by saline or scopolamine followed 10 minutes later by saline or ethanol treatment. Locomotor activity was assessed for 30 minutes following the third injection; n = 14 to 15 female DBA/2J mice/group. (A) Shown are cumulative data for the first 5 minutes of the test. *Significant difference in activity levels between 0 mg/kg SCH-23390 + 0 mg/kg scopolamine + 0 g/kg ethanol and 0 mg/kg SCH-23390 + 0.5 mg/kg scopolamine + 0 g/kg ethanol (p < 0.05). #Significant difference in activity levels between 0 mg/kg SCH-23390 + 0 mg/kg scopolamine + 0 g/kg ethanol and 0 mg/kg SCH-23390 + 0 mg/kg scopolamine + 1.5 g/kg ethanol (p < 0.05). %Significant difference in activity levels between 0 mg/kg SCH-23390 + 0 mg/kg scopolamine + 1.5 g/kg ethanol and 0 mg/kg SCH-23390 + 0.5 mg/kg scopolamine + 1.5 g/kg ethanol (p < 0.05). (B) Shown are cumulative data for the total 30-minute test period. *Significant difference in activity levels between 0 mg/kg SCH-23390 + 0 mg/kg scopolamine + 0 g/kg ethanol and 0 mg/kg SCH-23390 + 0.5 mg/kg scopolamine + 0 g/kg ethanol (p < 0.05). %Significant difference in activity levels between 0 mg/kg SCH-23390 + 0mg/kg scopolamine + 1.5 g/kg ethanol and 0 mg/kg SCH-23390 + 0.5 mg/kg scopolamine + 1.5 g/kg ethanol (p < 0.05).