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. Author manuscript; available in PMC: 2010 Apr 20.
Published in final edited form as: Alcohol Clin Exp Res. 2008 Dec 13;33(3):435–447. doi: 10.1111/j.1530-0277.2008.00854.x

Fig. 6.

Fig. 6

Haloperidol attenuates ethanol’s stimulant effects alone but not the locomotor activation following scopolamine or the scopolamine + ethanol combination. Shown are Day 3 minus Day 2 drug stimulation scores. Mice were treated with saline or haloperidol followed 2 minutes later by saline or scopolamine followed 10 minutes later by saline or ethanol treatment. Locomotor activity was assessed for 30 minutes following the third injection; n = 11 to 12 female DBA/2J mice/group. (A) Shown are cumulative data for the first 5 minutes of the test. *Significant difference in activity levels between 0 mg/kg haloperidol + 0 mg/kg scopolamine + 0 g/kg ethanol and 0.16 mg/kg haloperidol + 0 mg/kg scopolamine + 0 g/kg ethanol (p < 0.05). #Significant difference in activity levels between 0 mg/kg haloperidol + 0 mg/kg scopolamine + 0 g/kg ethanol and 0 mg/kg haloperidol + 0 mg/kg scopolamine + 1.5 g/kg ethanol (p < 0.05). &Significant difference in activity levels between 0 mg/kg haloperidol + 0 mg/kg scopolamine + 0 g/kg ethanol and 0 mg/kg haloperidol + 0.5 mg/kg scopolamine + 0 g/kg ethanol (p < 0.05). @Significant difference in activity levels between 0 mg/kg haloperidol + 0 mg/kg scopolamine + 0 g/kg ethanol and 0 mg/kg haloperidol + 0.5 mg/kg scopolamine + 1.5 g/kg ethanol (p < 0.05). %Significant difference in activity levels between 0 mg/kg haloperidol + 0 mg/kg scopolamine + 1.5 g/kg ethanol and 0.08–0.16 mg/kg haloperidol + 0 mg/kg scopolamine + 1.5 g/kg ethanol (p < 0.05). (B) Shown are cumulative data for the total 30-minute test. &Significant difference in activity levels between 0 mg/kg haloperidol + 0 mg/kg scopolamine + 0 g/kg ethanol and 0 mg/kg haloperidol + 0.5 mg/kg scopolamine + 0 g/kg ethanol (p < 0.05). @Significant difference in activity levels between 0 mg/kg haloperidol + 0 mg/kg scopolamine + 0 g/kg ethanol and 0 mg/kg haloperidol + 0.5 mg/kg scopolamine + 1.5 g/kg ethanol (p < 0.05).