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(A) Sequence and secondary structure of the theophylline-binding aptamer. The conserved region is boxed with bases in bold. The 3MX-binding aptamer used here has C22 changed to A22 and C27 changed to A27. (B) Chemical structures of theophylline and 3-methylxanthine. (C) NMR structure of the theophylline binding aptamer-theophylline complex (1EHT) showing only the conserved region, with bases 10 and 27 labeled in blue. The theophylline ligand is shown in sticks.
