Table 1.
SLCO expression at the protein (P) and mRNA (m) level in normal and cancerous human tissues. Each color represents a different gene family.
| Approved gene symbol | Expression in human normal tissue | Expression in human tumor tissue |
|---|---|---|
| SLCO1A2 | Liver (m; P), Brain (m), blood barrier (P), Kidney (m; P), Testis (m), Prostate (m), Breast (m), Retina (m) | Glioma (m;P); Bone tumors (m) |
| SLCO1B1 | Liver (m; P), Mononuclear cells (m) | HCC (m; P); Colorectal Cancer (m) |
| SLCO1B3 | Liver (m; P), Cervix (m), Mononuclear cells (m) | Colon Cancer (m; P); Breast cancer (P); Non Small Cell Lung Cancer (m); HCC (m; P) |
| SLCO1C1 | Brain (m); Testis (m; P), Heart (m), Retina (m), Breast (m) | Glioma (m); Bone tumors (m) |
| SLCO2A1 | Ubiquitous (protein detected only in GI tract tissue) | Colon cancer (m); Lung cancer (m); Bone tumor (m), Breast cancer (m) |
| SLCO2B1 | Ubiquitous (protein detected only in liver tissue) | Glioma (m; P); Colon cancer (m); Lung cancer (m); Bone tumors (m); Breast cancer (m) |
| SLCO3A1 | Ubiquitous and also in Peripheral Blood Mononuclear Cells (PBMC) (data available only on mRNA level) | Lung cancer (m); Colon cancer (m); Bone tumors (m); Breast cancer (m) |
| SLCO4A1 | Ubiquitous (protein detected only in brain and placenta tissues) | Glioma (m); Lung cancer (m); colon cancer(m), Bone tumor (m); Breast cancer (m) |
| SLCO4C1 | Kidney (m), Lung (m), Skin (m), PBMC (m), Kidney (m), Liver (m), Neutrophils (m), Breast (m), peripheral leukocytes (m) | Lung cancer (m); Bone tumor (m); Breast cancer (m) |
| SLCO5A1 | Prostate (m), Skeletal muscles (m), Thymus (m), Classically activated macrophages (m), Breast (m). | Bone tumors (m); Breast cancer (m) |
| SLCO6A1 | Testis (m), Spleen (m), Brain (m) (especially fetal brain), Placenta (m) | Non small cell lung cancer (m); Bladder cancer (m); Esophagus cancer (m); medulloblastoma (m) |