Table 2.
Summary of the significant HIF pathway candidate genes for the four test statistics used to detect signatures of positive selection
| Test for natural selection | ||||
|---|---|---|---|---|
| Gene name |
LSBL | lnRH | Tajima's D Difference |
WGLRH |
| ADRA1B | X | |||
| ARNT2 | X | |||
| ATP1A1 | X | |||
| ATP1A2 | X | |||
| CDH1 | X | X | ||
| COPS5 | X | |||
| CXCR4 | X | |||
| EDN1 | X | |||
| EDNRA | X | X | X | |
| EGLN1 | X | |||
| EGLN2 | X | |||
| ELF2 | X | X | ||
| FRAP1 | X | |||
| IL1A/ | X | |||
| IL1B | ||||
| IL6 | X | |||
| IGFBP1 | X | |||
| IGFBP2 | X | |||
| MDM2 | X | |||
| MMP2 | X | |||
| NOS1 | X | |||
| NOS2A | X | X | X | |
| NOTCH1 | X | |||
| NRP1 | X | |||
| NRP2 | X | |||
| POLRA | X | |||
| PIK3CA | X | X | ||
| PIK3CG | X | |||
| PRKAA1 | X | X | X | |
| PRKAA2 | X | |||
| SNAI3 | X | |||
| SPRY2 | X | |||
| TF | X | |||
| TGFA | X | |||
| TNC | X | X | ||
| TNF | X | |||
| VEGF | X | X | ||
LSBL = locus-specific branch length; lnRH = natural log of the ratio of heterozygosities; WGLRH = whole-genome long-range haplotype.