Table 2.

Characteristics of 10 White HEIRS Study Participants with Abnormal Thyroid-Related Measures

Conditiona	Age, sexb	HFE genotype	Thyroid-stimulating hormone (TSH), mIU/L	Free thyroxine (T4), ng/dL	Serum ferritin, ng/mLc
Hypothyroidism	20s F	wt/wt	291	0.16	23
Hypothyroidism	50s F	wt/wt	88.9	0.36	90
Hypothyroidism	50s F	wt/wt	19.4	0.69	27
Hyperthyroidism	50s M	C282Y/C282Y	0.014	2.04	24
Hyperthyroidism	20s F	C282Y/C282Y	0.009	1.98	124
Hyperthyroidism	70s M	C282Y/C282Y	0.007	4.59	1,462
Hyperthyroidism	40s M	wt/wt	0.064	2.11	144
Hyperthyroidismd	50s M	wt/wt	0.054	2.07	230
Hyperthyroidism	80s M	wt/wt	0.015	2.35	199
Hyperthyroidismd	40s F	wt/wt	0.011	2.73	124

^aWe defined hypothyroidism as the concurrence of TSH >5.00 mIU/L and free T4 <0.70 ng/dL, and hyperthyroidism as the concurrence of TSH <0.400 mIU/L and free T4 >1.85 ng/dL. These measurements were performed at the time of post-initial screening examination. For display of TSH values, we used three significant figures.

^bIt is the privacy policy of the HEIRS Study to display the age of individual subjects by decade.

^cThe mean serum ferritin level was lower in participants with hypothyroidism than in those with hyperthyroidism (38 ng/mL vs. 167 ng/mL, respectively; p = 0.0446).

^dThese participants reported that they took thyroid supplements.