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Monoubiquitylation induces dynamin-mediated internalization of the TCR:CD3 complex followed by lysosomal degradation. Thymic lobes from neonatal mice (P1) were treated with the inhibitors indicated for 20 h, and surface TCRβ expression determined by flow cytometry. Data represent the mean±s.e.m. of 5–8 mice from 2 to 3 experiments per group (A, B) or 5–10 mice from 2 to 3 experiments per group (C). A full-colour version of this figure is available at The EMBO Journal Online.
