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. 2010 Feb 25;29(7):1205–1214. doi: 10.1038/emboj.2010.20

Figure 4.

Figure 4

A comparison between the switch-II of Ras and Rap. (A) Superimposition of Rap1B (yellow) (PDB entry 3BRW) extracted from Rap1B-Rap1GAP onto the structure (PDB entry 1WQ1) of the complex between Ras (cyan) and the GAP domain of p120GAP (green) domain. SynGAP (orange) (PDB entry 3BXJ) and NF1 (magenta) (PDB entry 1NF1) GAP domain structures are aligned to p120GAP to show the similarity between different GAP domains. (B) A detailed view of the active centre. Important residues in Ras and Rap switch-II are highlighted, as well as the proline in helix-α6 in the three GAP domains. (C) Sequence alignment of the switch-II regions of Ras and Rap. Residues differing around position 61 and mutated in this work are indicated by an asterisk.