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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Pharm Sci. 2010 Jun;99(6):2557–2575. doi: 10.1002/jps.22054

Table 3.

List of well accepted protein/peptide drug formulations based on biodegradable microparticles in the market.

Brand Name Type of Particulate System Parent Drug Indication Approval Year
Lupron Depot® PLA Microspheres Leuprolide acetate Prostate cancer 1993
Nutropin Depot® PLGA Microspheres Growth hormone (Somatropin recombinant) Pediatric growth hormone deficiency 1999
Sandostatin LAR® Depot PLGA Microspheres Octreotide acetate Acromegaly 1988
Somatuline® LA PLGA microspheres Lanreotide Acromegaly 2007
Trelstar™ Depot PLGA microsphere Triptorelin pamoate Prostate cancer 2008