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Effect of mutations on binding properties of mAb 2E2. See text for definition of metrics, which are derived from ChemScore values expressed in kJ/mol.
| Mutation | specificity change | cocaine affinity change |
|---|---|---|
| wild-type | 0.0 | 0.0 |
| Glu211Ala | −0.2 | 1.6 |
| Leu212Asp | 0.1 | −1.8 |
| Tyr99Glu/Leu212Asp | 0.3 | −2.2 |
| Tyr99Ser/Leu212Ser | 0.3 | −2.2 |
| Tyr99Glu | 0.6 | −0.3 |
