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The effect of third ventricular infusion of aCSF (a) or leptin (10 μg/h; b) for 72 h on plasma LH levels in lean hypogonadotropic OVX ewes. 10-min blood samples were collected for 6 h prior to the infusion and for the final 6 h of the infusion period. c Analysis of mean LH concentration (ng/ml), LH pulse amplitude (ng/ml), LH interpulse interval (min) and LH pre-pulse nadir (ng/ml). Arrowheads indicate an LH pulse. * p < 0.05 and ** p < 0.01 compared to pre-infusion values.
