Table 4.

Associations between baseline OH and cognitive decline over an approximate 6-year period of the ARIC Study (OR, with 95% CI in parentheses)

Covariates included	Delayed word recall	Digit symbol substitution	Word fluency
(1) Age	1.21 (0.99–1.48)	1.28 (1.04–1.58)	1.11 (0.90–1.38)
(2) Model 1 + race/center, gender and education	1.16 (0.95–1.42)	1.14 (0.91–1.41)	1.03 (0.82–1.28)
(3) Model 2 + systolic BP and antihypertensive medications	1.15 (0.94–1.42)	1.13 (0.90–1.40)	1.03 (0.82–1.28)
(4) Model 3 + selected risk factors and conditions	1.08 (0.86–1.35)	1.05 (0.83–1.35)	1.03 (0.80–1.31)

Cognitive decline defined as the quintile of the largest decrease on test performance. Risk factors in model 4: current drinking, current smoking, diabetes, carotid intima-media thickness, low ankle-brachial index, low-density lipoprotein cholesterol, resting heart rate, prevalent CHD, cancer and fair/poor self-reported health.