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Silencing of S1PR1 using custom-pooled siRNA significantly reduced HUVEC invasion. A) Extracts taken from 3-D invading cultures (16 h) were probed with antisera directed to S1P1 in Western Blot analysis. B) Invading cultures were fixed, stained, and photographed (side-view) at 24 h. C) Invasion density was quantified by counting the average numbers of invading cells per standardized field (n = 3 fields; mean ± SEM). P < 0.05. Results are representative of duplicate experiments.
