FIG. 3.

Signaling pathways required for HBEGF induction of extravillous differentiation. The number of SW.71 (upper panels) or HTR-8/SVneo (lower panels) cells migrating through a fibronectin-coated transwell membrane insert and into the lower chamber were measured after culture in the absence (striped bars) or presence (stippled bars) of 1 nM HBEGF, with kinase inhibitors (black bars) or the corresponding inactive structural analogue (white bars), as indicated. Values represent the average ± SEM of at least three experiments; *P < 0.05.