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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Nat Struct Mol Biol. 2010 Jan 10;17(2):159–164. doi: 10.1038/nsmb.1737

Figure 5. Model of the potential mechanism for activation of ALDH2 by Alda-1.

Figure 5

The structure of the Alda-1 complex was used to model a quaternary complex between ALDH2, coenzyme, acyl-enzyme intermediate and Alda-1. For this figure, the position of reduced coenzyme is shown in the ‘hydrolysis position’, whereas the hydride transfer position puts the nicotinamide ring in the space between Cys302 and Glu268. A butyryl group (magenta) is shown as the acyl-enzyme intermediate and a crystallographically observed water molecule (magenta sphere) is shown between Cys302 and Glu 268. The figure was generated using PyMol for Windows25.