Table 2.
Self-Reported NSAID use among Cases and Controls
| NSAID use | SCC n = 415 | Controls n = 415 | Crude OR (95% CI) | Adjusted OR* (95% CI) |
|---|---|---|---|---|
| Any NSAID | ||||
| Any use | ||||
| Never/occasional | 153 (37%) | 172 (41%) | 1.0 (referent) | 1.0 (referent) |
| Regular∎ | 262 (63%) | 243 (59%) | 1.21(0.92, 1.60) | 1.32 (0.92, 1.89) |
| Duration (yrs)◇ | ||||
| <1 | 149 (36%) | 172 (42%) | 1.0 (referent) | 1.0 (referent) |
| 1–3 | 57 (14%) | 39 (9%) | 1.68 (1.06,2.67) | 1.94 (1.10,3.44) |
| 4–9 | 95 (23%) | 99 (24%) | 1.09 (0.76, 1.55) | 1.20 (0.76, 1.89) |
| 10+ | 114 (27%) | 105 (25%) | 1.25 (0.88,1.76) | 1.30 (0.82,2.07) |
| P for Trend | 0.70 | 0.69 | ||
| Pill-years¶ | ||||
| 0 | 125 (30%) | 151 (37%) | 1.0 (referent) | 1.0 (referent) |
| >0–2 | 49 (12%) | 33 (8%) | 1.82 (1.09,3.04) | 2.40 (1.26, 4.57) |
| >2–5 | 49 (12%) | 51 (12%) | 1.13 (0.72,1.78) | 1.60 (0.89, 2.89) |
| >5 | 192 (46%) | 180 (43%) | 1.29 (0.94, 1.76) | 1.25 (0.83, 1.90) |
| P for Trend | 0.63 | 0.71 | ||
| Aspirin | ||||
| Any use | ||||
| Never/occasional | 207 (50%) | 226 (54%) | 1.0 (referent) | 1.0 (referent) |
| Regular∎ | 208 (50%) | 189 (46%) | 1.21 (0.92, 1.60) | 1.38 (0.96, 1.97) |
| Dose▴ | ||||
| Low dose (≤81 mg) | 342 (82%) | 339 (82%) | 1.0 (referent) | 1.0 (referent) |
| High dose(> 81 mg) | 73 (18%) | 76 (18%) | 0.95 (0.66, 1.36) | 0.86 (0.54, 1.38) |
| Duration (yrs)◇ | ||||
| <1 | 207 (50%) | 226 (55%) | 1.0 (referent) | 1.0 (referent) |
| 1–3 | 50 (12%) | 35 (8%) | 1.56 (0.97,2.49) | 1.53 (0.86,2.75) |
| 4–9 | 74 (18%) | 75 (18%) | 1.08 (0.74,1.56) | 1.41 (0.88,2.28) |
| 10+ | 84 (20%) | 79 (19%) | 1.17 (0.81,1.69) | 1.23 (0.75,2.02) |
| P for Trend | 0.88 | 0.52 | ||
| Pill-years¶ | ||||
| 0 | 207 (50%) | 226 (54%) | 1.0 (referent) | 1.0 (referent) |
| >0 – 2 | 49 (12%) | 33 (8%) | 1.62 (1.00, 2.61) | 1.79 (0.98, 3.26) |
| >2 – 5 | 52 (13%) | 51 (12%) | 1.12 (0.72, 1.72) | 1.33 (0.75, 2.34) |
| >5 | 107 (26%) | 105 (25%) | 1.11 (0.79, 1.55) | 1.24 (0.79, 1.92) |
| P for Trend | 0.92 | 0.67 | ||
| Pill-years-dose¤ | ||||
| 0 | 226 (54%) | 207 (50%) | 1.0 (referent) | 1.0 (referent) |
| >0 – 2.5 | 132 (32%) | 152 (37%) | 1.26 (0.93, 1.71) | 1.60 (1.07,2.39) |
| >2.5 – 10 | 47 (11%) | 45 (11%) | 1.06 (0.66, 1.70) | 1.00 (0.53,1.88) |
| >10 | 10 (2%) | 11 (3%) | 1.15 (0.49, 2.72) | 0.75 (0.23,2.38) |
| P for Trend | 0.85 | 0.46 | ||
| Ibuprofen | ||||
| Any use | ||||
| Never/occasional | 340 (82%) | 343 (83%) | 1.0 (referent) | 1.0 (referent) |
| Regular∎ | 75 (18%) | 72 (17%) | 1.05 (0.73, 1.52) | 0.74 (0.46, 1.19) |
| Dose▴ | ||||
| Low dose (≤200 mg) | 355 (86%) | 364 (88%) | 1.0 (referent) | 1.0 (referent) |
| High dose(>200 mg) | 60 (14%) | 51 (12%) | 1.21 (0.81, 1.83) | 0.85 (0.50, 1.43) |
| Duration (yrs)◇ | ||||
| <1 | 340 (82%) | 343 (83%) | 1.0 (referent) | 1.0 (referent) |
| 1–3 | 15 (4%) | 19 (5%) | 0.79 (0.39, 1.60) | 0.74 (0.32, 1.71) |
| 4–9 | 33 (8%) | 32 (8%) | 1.05 (0.61, 1.79) | 0.63 (0.31, 1.24) |
| 10+ | 27 (7%) | 21 (5%) | 1.28 (0.72, 2.27) | 0.90 (0.43, 1.89) |
| P for Trend | 0.30 | 0.70 | ||
| Pill-years¶ | ||||
| 0 | 340 (82%) | 343 (83%) | 1.0 (referent) | 1.0 (referent) |
| >0 – 2 | 12 (3%) | 12 (3%) | 1.01 (0.45, 2.26) | 0.69 (0.26, 1.80) |
| >2 – 5 | 23 (6%) | 23 (6%) | 1.02 (0.57, 1.83) | 0.85 (0.40, 1.80) |
| >5 | 40 (10%) | 37 (9%) | 1.09 (0.68, 1.75) | 0.70 (0.38, 1.30) |
| P for Trend | 0.76 | 0.44 | ||
| Pill-years-dose¤ | ||||
| 0 | 340 (82%) | 343 (83%) | 1.0 (referent) | 1.0 (referent) |
| >0 – 2.5 | 12 (3%) | 15 (4%) | 0.82 (0.38, 1.77) | 0.66 (0.27, 1.64) |
| >2.5 – 10 | 24 (6%) | 20 (5%) | 1.19 (0.66, 2.17) | 0.95 (0.45, 2.04) |
| >10 | 39 (9%) | 37 (9%) | 1.05 (0.65, 1.72) | 0.64 (0.33, 1.23) |
| P for Trend | 0.54 | 0.38 | ||
| Non-aspirin NSAID | ||||
| Any use | ||||
| Never/occasional | 307 (74%) | 313 (75%) | 1.0 (referent) | 1.0 (referent) |
| Regular∎ | 108 (26%) | 102 (25%) | 1.08 (0.79, 1.48) | 0.84 (0.56, 1.26) |
| Duration (yrs)◇ | ||||
| <1 | 299 (72%) | 313 (75%) | 1.0 (referent) | 1.0 (referent) |
| 1–3 | 26 (6%) | 21 (5%) | 1.29 (0.72,2.31) | 1.34 (0.65, 2.77) |
| 4–9 | 47 (11%) | 47 (11%) | 1.05 (0.68, 1.64) | 0.68 (0.38, 1.12) |
| 10+ | 43 (10%) | 34 (8%) | 1.31 (0.83,2.07) | 1.05 (0.57, 1.91) |
| P for Trend | 0.45 | 0.59 | ||
| Pill-years¶ | ||||
| 0 | 322 (78%) | 333 (80%) | 1.0 (referent) | 1.0 (referent) |
| >0 – 2 | 14 (3%) | 14 (3%) | 1.53 (0.84,2.76) | 1.66 (0.81, 3.42) |
| >2 – 5 | 30 (7%) | 25 (6%) | 1.13 (0.66,1.91) | 1.03 (0.52, 2.05) |
| >5 | 49 (12%) | 43 (10%) | 1.35 (0.97, 1.87) | 1.02 (0.66, 1.57) |
| P for Trend | 0.36 | 0.61 | ||
| Acetaminophen | ||||
| Any use | ||||
| Never/occasional | 329 (79%) | 344 (83%) | 1.0 (referent) | 1.0 (referent) |
| Regular∎ | 86 (21%) | 71 (17%) | 1.25 (0.89, 1.77) | 1.15 (0.74, 1.81) |
| Duration (yrs)◇ | ||||
| <1 | 329 (79%) | 344 (83%) | 1.0 (referent) | 1.0 (referent) |
| 1–3 | 23 (6%) | 21 (5%) | 1.13 (0.60,2.15) | 1.14 (0.52,2.50) |
| 4–9 | 30 (7%) | 27 (7%) | 1.15 (0.68, 1.96) | 1.14 (0.57,2.30) |
| 10+ | 33 (8%) | 23 (6%) | 1.45 (0.85,2.46) | 1.18 (0.58,2.40) |
| P for Trend | 0.22 | 0.68 | ||
| Pill-years¶ | ||||
| 0 | 329 (79%) | 344 (83%) | 1.0 (referent) | 1.0 (referent) |
| >0 – 2 | 22 (5%) | 13(3%) | 1.80 (0.86, 3.76) | 2.74 (1.06, 7.10) |
| >2 – 5 | 20 (5%) | 26 (6%) | 0.78 (0.41, 1.46) | 0.59 (0.26, 1.32) |
| >5 | 44 (11%) | 32 (8%) | 1.41 (0.88, 2.25) | 1.18 (0.64, 2.19) |
| P for Trend | 0.83 | 0.35 | ||
Adjusted for eye color (blue/grey vs. other), natural hair color (red/blond vs. other), skin type (1–4 as described in Table 1), education (4-year college or above vs. not), history of sunburns (> 2 severe vs. ≤ 2 severe), history of high-risk exposures such as UV light, burn scar, non-healing ulcers, radiation treatment, arsenic exposure, exposure to industrial chemicals (yes/no), history of smoking (current vs. former/none), history of freckling (yes/no), outdoor sun exposure (> 2 hours per week between 10am and 4 pm), occupational sun exposure (yes/no), tanning bed use (yes/no), and family history of skin cancer (yes/no). Dummy variables were created for all missing values. 95% CI values are Wald estimates.
Years of use in past 10 years
At least once/week for at least one year
Average daily dose over the period of reported use
Number of pills per day x days per week x years of use. 1 pill-year is equivalent to 1 pill per day for one year.
Number of pills per day x days per week x years of use x strength per pill. 1 pill-years-dose is equivalent to 1 regular strength pill per day for 1 year