Table 2.

List of Compounds Discovered from the Screening of 5 Libraries (8284 compounds) and Whether the Compound or Its Mechanistic Class Was Previously Known to Disassemble the PNC

Library	Compound	Previously Discovered	Mechanistic Class	Mechanistic Class Known to Reduce PNC
LOPAC	(S)-(+)-camptothecin	[10]	Topo I inhibitor	Yes
	7-Chloro-4-hydroxy-2-phenyl-1,8-naphthyridine	No	Adenosine receptor antagonist	No
	Diphenyleneiodonium chloride	No	Nitric oxide synthase inhibitor	No
	Ellipticine	[10]	Intercalator	Yes
	Etoposide	[10]	Topo II inhibitor	Yes
	Genistein	Yes (our unpublished data)	Topo II inhibitor at high doses	Yes
	Mitoxantrone	[10]	Intercalator	Yes
	Methotrexate	[10]	Inhibits RNA synthesis	Yes
	Quinacrine dihydrochloride	No	Intercalator	Yes
NCGC in house	Acriflavinium	Yes (our unpublished data)	Intercalator	Yes
	9-Aminoacridine	Yes (our unpublished data)	Intercalator	Yes
	Daunorubicin	[10]	DNA intercalator and Topo II inhibitor	Yes
	3,6-Diaminoacridine	Yes (our unpublished data)	Intercalator	Yes
	Doxorubicin	[10]	DNA intercalator and Topo II inhibitor	Yes
	Mofetil	No	Nucleoside analog	Yes
	Topotecan	[10]	Topo I inhibitor	Yes
	Zidovudine	No	Nucleoside analog	Yes
Tocris/Timtec	Actinomycin D	[10]	DNA intercalator and Topo II inhibitor	Yes
	Camptothecin	[10]	Topo I inhibitor	Yes
	Chelidonine	No	Tubilin inhibitor	No
Prestwick	Camptothecin	[10]	Topo I inhibitor	Yes
	Daunorubicin	[10]	DNA intercalator and Topo II inhibitor	Yes
	Doxorubicin	[10]	DNA intercalator and Topo II inhibitor	Yes
Biomol	Actinomycin D	[10]	DNA intercalator and Topo II inhibitor	Yes
	(S)-(+)-Camptothecin	[10]	Topo I inhibitor	Yes
	Diphenyleneiodonium chloride	No	Nitric oxide synthase inhibitor	No
	Hydroxy-camptothecin	No	Topo I inhibitor	Yes

LOPAC, Library of Pharmacologically Active Compounds; NCGC, National Institutes of Health Chemical Genomics Center; PNC, perinucleolar compartment.