Figure 5. Gp120 induces apoptosis.
Rats were microinjected into the superior colliculus with FR and heat-inactivated gp120 (control) or FR and gp120. Animals were then sacrificed 3 or 18 days after the injection. The retinae were dissected and prepared for FR (A, C, and E) and caspase-3 (B, D and F) staining. Examples of RGC in control (A-B) and gp120-treated rats at 3 (C–D) and 18 days (E–F). Red=FR, green= caspase-3 immunoreactivity. Bar=40 μm.