Figure 3. MCM3 expression during acute oxyntic atrophy.
Sections from an untreated mouse (A) or mice treated with DMP-777 for 1 (B), 3 (C), 7 (D) or 14 (E) days were dual stained with antibodies against MCM3 (green) and antibodies against Ki67 (red). With increasing amounts of treatment DMP-777, we observed an increase in MCM3 staining in cells at the bases of glands (Scale bar: 40 µm). (F) Quantification of MCM3 and Ki-67 staining showed a significant increase in MCM3 staining at days 3–14 of treatment (green line, ** p<0.01; *** p<0.001). Ki-67 staining showed a smaller increase, which was only significant at 7 days of treatment (* p<0.05).