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. Author manuscript; available in PMC: 2010 Apr 21.
Published in final edited form as: Neuropharmacology. 1997 Jul;36(7):941–949. doi: 10.1016/s0028-3908(97)00074-9

Fig. 3.

Fig. 3

α subunit affects the efficacy, but not potency of PRO. Submaximal GABA was applied by picospritzer as detailed in Materials and Methods; anesthetics were applied to the bath. (A) PRO (0.05–50 μM) potentiates GABA-induced currents in both α1β3γ2 and α6β3γ2 GABAA receptors. Data points are means ± SEM from pooled experiments (4 ≤ n ≤ 13). (B) TCEt (0.02–10 mM) potentiates GABA-induced currents in both receptor combinations (5 ≤ n ≤ 15; pooled data are shown).