Graph showing the mean distance covered ±SEM in the open field as an indication of locomotor activity. Factorial ANOVA revealed that the non-exercised rats covered a greater distance in the open field (* p < 0.01) than exercised rats. MSnR = maternally separated non-runners, n = 11; nMSnR = non-separated non-runners, n = 13; MSR = maternally separated runners, n = 10, nMSR = non-separated runners, n = 11.