TABLE I.
Demographic and Clinical Characteristics of Participants According to VHL598C>T Status
| Characteristics |
VHL wild type (n = 32) |
VHL598C>T heterozygote (n = 4) |
VHL598C>T homozygote (n = 34) |
P (homozygote vs. wild type) |
|---|---|---|---|---|
| Male (%)a | 15 (47%) | 2 (50%) | 12 (35%) | 0.8 |
| Age (years) | 44 (15–50) | 8 (6–13) | 18 (13–51) | 0.6 |
| BMI (kg/m2) | 20.6 (18.4–24.2) | 14.7 (13.8–19.0) | 19.6 (16.8–22.9) | 0.3 |
| History of smokinga | 6 (19%) | 0 (0%) | 5 (15%) | 0.7 |
| History of alcohol consumptiona | 2 (7%)b | 0 (0%) | 2 (7%)c | 0.9 |
| Systolic blood pressure (mmHg) | 110 (102–120) | 99 (93–112) | 105 (95–116) | 0.032 |
| Diastolic blood pressure (mmHg) | 72 (64–80) | 65 (58–75) | 69 (60–80) | 0.3 |
| Hemoglobin (g/dL) | 13.7 (12.4–14.5) | 14.4 (14.0–15.3) | 18.6 (16.7–20.2) | 0.0001 |
| Hematocrit (%) | 39.4 (36.2–43.1) | 43.0 (40.7–44.2) | 55.7 (51.8–59.2) | 0.0001 |
| MCV (ft) | 90.1 (85.7–95.5) | 85.5 (82.5–87.7) | 87.6 (79.4–91.2) | 0.051 |
| White blood cell (103/mm3) | 5.8 (5.2–6.7) | 5.5 (5.0–8.1) | 5.0 (4.3–5.8) | 0.009 |
| Platelets (103/mm3) | 305 (247–355) | 403 (369–444) | 242 (178–322) | 0.029 |
| Lymphocyte% | 37.3 (35.8–46.2) | 49.3 (46.9–66.1) | 44.0 (39.7–49.9) | 0.2 |
| Lymphocyte counts (103/mm3) | 2.4 (1.9–2.8) | 2.7 (2.4–5.5) | 2.1 (1.8–2.6) | 0.1 |
Results in median and interquartile range, unless otherwise specified.
a
Number (%).
b
N = 27.
c
N = 29.