Table 1.
Demographics and baseline characteristics both overall and by baseline statin use
| Overall (n = 1,141) | Statin users (n = 287) | Statin nonusers (n = 854) | p Value | |
|---|---|---|---|---|
| Age at baseline, y | 77.3 ± 5.3 | 76.4 ± 4.7 | 77.6 ± 5.5 | 0.0003 |
| Years of education | 11.3 ± 2.6 | 11.2 ± 2.7 | 11.3 ± 2.6 | 0.7536 |
| Female | 791 (69.3) | 185 (64.5) | 606 (71.0) | 0.0388 |
| Any ApoE ε4 alleles | 390 (34.2) | 108 (37.6) | 282 (33.0) | 0.1543 |
| Baseline cognitive score | 31.1 ± 1.7 | 31.3 ± 1.6 | 31.0 ± 1.7 | 0.0564 |
| BMI at baseline | 30.9 ± 6.6 | 32.0 ± 6.6 | 30.6 ± 6.6 | 0.0013 |
| Hypertension | 1037 (90.9) | 278 (96.9) | 759 (88.9) | <0.0001 |
| History of smoking | 619 (54.5) | 160 (55.9) | 459 (54.1) | 0.5807 |
| History of alcohol use | 403 (35.9) | 118 (41.8) | 285 (33.9) | 0.0165 |
| History of stroke | 169 (14.9) | 58 (20.4) | 111 (13.0) | 0.0027 |
| History of diabetes | 328 (28.9) | 126 (44.2) | 202 (23.8) | <0.0001 |
| History of heart disease | 195 (17.1) | 83 (28.9) | 112 (13.2) | <0.0001 |
| History of depression | 112 (9.9) | 27 (9.4) | 85 (10.1) | 0.7621 |
| Cholesterol >200 mg/dL | 387 (34.6) | 54 (18.9) | 333 (39.9) | <0.0001 |
| LDL-C >130 | 314 (28.1) | 41 (14.4) | 273 (32.7) | <0.0001 |
| Human C-reactive protein (>2 mg/L) | 813 (76.3) | 195 (72.0) | 618 (77.8) | 0.0493 |
| Use of estrogen (women only) | 82 (10.4) | 23 (12.4) | 59 (9.7) | 0.2923 |
| Use of NSAIDs | 518 (45.4) | 166 (57.8) | 352 (41.2) | <0.0001 |
| Use of antiplatelet medication/aspirin | 385 (33.7) | 143 (49.8) | 242 (28.3) | <0.0001 |
Values are mean ± SD or n (%).
BMI = body mass index; LDL-C = low-density lipoprotein cholesterol; NSAIDs = nonsteroidal anti-inflammatory drugs.