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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Biomark Med. 2010 Feb;4(1):171–189. doi: 10.2217/bmm.09.68

Figure 6. Diagnostic thresholds used in combination predict a screening diagnosis of periodontal disease.

Figure 6

(A) Levels of IL-1β above the threshold (red line) demonstrate a sensitivity of 66%, specificity of 98.3%, positive predictive value of 91.7% and negative predictive value of 91.2% for the diagnosis of periodontal disease. (B) Levels of matrix metalloproteinase-8 above the threshold (red line) demonstrate a sensitivity of 40%, specificity of 98.3%, positive predictive value of 90% and negative predictive value of 85.5%. Samples elevated above both thresholds have a positive predictive value of 96% or higher. All samples analyzed by standard enzyme immunoassays. SD: Standard deviation.