Table 2.

Effects of genetic manipulations of angiotensin II receptors on development of atherosclerosis in mice

Receptor deficiency	Model	Gender	Atherosclerosis effect	Study
Whole body deficiency
AT1a	LDL receptor -/-	Male and female	Decrease	Daugherty et al. [11]
	apoE -/-	Male	Decrease	Wassmann et al. [27]
			Decrease	Li et al. [28]
			Decrease	Tomono et al. [30]
			Decrease	Eto et al. [29]
	Diabetic apoE-/-		Decrease	Ihara et al. [33]
AT2	LDL receptor -/-	Male and female	No effect	Daugherty et al. [11]
	apoE-/-	Male	Increase	Iwai et al. [39]
			No effect on size, but composition change	Sales et al. [38]
	Diabetic apoE-/-		Decrease	Koitka et al. [37]
Bone marrow transplantation
AT1a	LDL receptor -/-; AngII infused	Male	No effect in AT1aR -/-; modest decrease in +/+	Cassis et al. [31]
	apoE -/-; AngII infused		No effect in AT1aR -/-; modest decrease in +/+	Koga et al. [35]
	LDL receptor -/-		No effect	Lu et al. [7•]
	apoE -/-		Decrease	Fukuda et al. [32]
			Decrease	Tsubakimoto et al. [34]
			Increase	Kato et al. [36]

AngII angiotensin II, apoE apolipoprotein E, LDL low-density lipoprotein