Table 5.
Personal history of infectious disease and risk of lymphoplasmacytic lymphoma-Waldenström macroglobulinemia (LPL-WM)*
| WM patients |
LPL patients |
LPL-WM patients |
|||||||
| Category or condition | No. of WM case patients (n = 1823) | No. of control subjects (n = 7158) | OR (95% CI) | No. of LPL case patients (n = 647) | No. of control subjects (n = 2540) | OR (95% CI) [P] | No. of LPL-WM case patients (n = 2470) | No. of control subjects (n = 9698) | OR (95% CI) |
| Total infections† | 278 | 856 | 1.4 (1.2 to 1.6) | 80 | 288 | 1.1 (0.9 to 1.45) | 358 | 1144 | 1.3 (1.1 to 1.45) |
| Pneumonia | 95 | 268 | 1.5 (1.1 to 1.8) | 24 | 88 | 1.1 (0.7 to 1.7) | 119 | 356 | 1.4 (1.1 to 1.7) |
| Tuberculosis | 13 | 38 | 1.4 (0.8 to 2.7) | 1 | 9 | 0.4 (0.1 to 2.6) | 14 | 47 | 1.2 (0.6 to 2.1) |
| Intestinal infection | 33 | 116 | 1.2 (0.8 to 1.8) | 13 | 32 | 1.4 (0.8 to 2.5) | 46 | 148 | 1.3 (0.9 to 1.8) |
| Septicemia | 16 | 27 | 2.6 (1.4 to 4.8) | 2 | 3 | 1.4 (0.3 to 5.8) | 18 | 30 | 2.4 (1.2 to 4.3) |
| Herpes simplex | 3 | 5 | 2.2 (0.6 to 8.5) | 0 | 2 | 0 [1.00] | 3 | 7 | 1.7 (0.4 to 6.5) |
| Herpes zoster | 26 | 25 | 4.2 (2.5 to 7.0) | 1 | 8 | 0.5 (0.1 to 4.0) | 27 | 33 | 3.4 (2.0 to 5.6) |
| Infectious mononucleosis | 1 | 2 | 2.4 (0.2 to 23.2) | 0 | 1 | 0 [1.00] | 1 | 3 | 1.4 (0.2 to 13.5) |
| Pyelonephritis | 25 | 71 | 1.5 (0.9 to 2.3) | 12 | 20 | 2.4 (1.3 to 4.4) | 37 | 91 | 1.7 (1.1 to 2.5) |
| Cystitis | 18 | 96 | 0.8 (0.5 to 1.3) | 5 | 29 | 0.6 (0.3 to 1.6) | 23 | 125 | 0.8 (0.5 to 1.2) |
| Sinusitis | 13 | 16 | 2.9 (1.5 to 5.7) | 4 | 10 | 2.2 (0.7 to 6.3) | 17 | 26 | 2.7 (1.4 to 4.9) |
| Otitis media | 10 | 39 | 1.0 (0.5 to 2.0) | 7 | 14 | 1.9 (0.8 to 4.1) | 17 | 53 | 1.3 (0.7 to 2.2) |
| Nasopharyngitis or laryngitis | 6 | 21 | 1.1 (0.5 to 2.7) | 1 | 7 | 0.6 (0.1 to 4.4) | 7 | 28 | 1.0 (0.4 to 2.3) |
| Influenza | 19 | 21 | 3.2 (1.8 to 5.8) | 3 | 10 | 1.8 (0.54 to 5.91) | 22 | 31 | 2.9 (1.7 to 5.0) |
| Meningitis | 3 | 8 | 1.2 (0.4 to 4.3) | 1 | 6 | 0.8 (0.1 to 6.6) | 4 | 14 | 1.1 (0.4 to 3.4) |
| Pericarditis | 2 | 20 | 0.4 (0.1 to 1.8) | 2 | 7 | 1.0 (0.3 to 4.2) | 4 | 27 | 0.6 (0.2 to 1.7) |
| Myocarditis | 2 | 5 | 1.3 (0.3 to 6.3) | 0 | 4 | 0 [.59] | 2 | 9 | 0.9 (0.2 to 4.1) |
| Endocarditis | 3 | 22 | 0.5 (0.2 to 1.6) | 0 | 8 | 0 [.37] | 3 | 30 | 0.4 (0.1 to 1.3) |
| Osteomyelitis | 1 | 17 | 0.3 (0.0 to 1.9) | 0 | 5 | 0 [.59] | 1 | 22 | 0.2 (0.0 to 1.4) |
| Gingivitis and periodontitis | 17 | 58 | 1.1 (0.7 to 1.8) | 3 | 23 | 0.6 (0.2 to 2.0) | 20 | 81 | 1.0 (0.6 to 1.6) |
| Tonsillitis | 5 | 18 | 1.2 (0.5 to 3.2) | 3 | 4 | 2.2 (0.6 to 7.5) | 8 | 22 | 1.4 (0.6 to 3.3) |
| Fasciitis | 3 | 4 | 3.6 (0.8 to 16.3) | 0 | 0 | — | 3 | 4 | 2.9 (0.6 to 12.8) |
| Empyema | 2 | 5 | 2.5 (0.5 to 12.7) | 0 | 0 | — | 2 | 5 | 1.7 (0.3 to 8.6) |
| Erysipelas (cellulitis) | 22 | 108 | 0.8 (0.5 to 1.3) | 12 | 31 | 1.4 (0.8 to 2.5) | 34 | 139 | 1.0 (0.7 to 1.4) |
*
When presented in square brackets, P values (two-sided) that were based on Fisher exact test are given when no case patient or control subjects have the specified condition. Odds ratios (ORs) were adjusted for categorical year of birth, date of diagnosis, gender, and county. CI = confidence interval.
†
Overall categories that total to less than the sum of the individual categories because some individuals have more than one infectious disease.