FIG. 2.

Bayes factors comparing the HLA-B*57-restricted epitope model to the nonepitope model at each site in HIV-1 Gag p17 and p24. Shaded regions indicate the degree of evidence in favor of the epitope model: white indicates negligible evidence, light gray indicates positive evidence, intermediate gray indicates strong evidence, and dark gray indicates definitive evidence (Kass and Raftery 1995). Prominent escape mutations known to be associated with the HLA-B*57 allele are annotated. Black dots indicate sites with a significant (q < 0.2) association between host HLA and HIV mutations as determined by the phylogenetically corrected method described in Bhattacharya et al. (2007).