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Illustration of epigenetic modifications at rDNA. (A) Micrographs of primary mouse embryonic fibroblasts with single, densely stained nucleoli (Nu). (B) Detail of nucleolus with known epigenetic modifications to rDNA. (C) Scheme of epigenetic regulation of rDNA transcription and silencing. (D) Silver-stained NORs (Ag-NORs) in SUV39h wild-type (wt) and (E) SUV39h double null (dn) fibroblasts. SUV39h deficiency caused changes in the morphology of Ag-NORs. Bar = 1 μm.
