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. 2010 May;58(5):391–403. doi: 10.1369/jhc.2009.955435

Figure 3.

Figure 3

An example of selected histone modifications and how HDAC and Dnmts inhibitors change their nucleolar compartment localization. (A1) H3K9me2 in control and 5-azacytidine–treated human small-cell-lung carcinoma A549 cells. (A2) H3K9me2 in centromeric regions of human acrocentric chromosomes 14 and 22 (adapted from Skalníková et al. 2007). (B) H3K4me2 in control and TSA-treated A549 cells. TSA caused an increase in H3K4me2 in the nucleolar compartment (white frame). (C1) Absence of H3K4me2 at centromeres 14 and 22 (red spots). (C2) Association of centromere of human Y chromosome (red spot) with nucleoli. (C3) Absence of H3K9 acetylation at centromeres of human chromosomes (HSA) 9 (red) and 10 (green) in control and TSA-treated A549 cells. Both chromosomes associated with nucleoli even though they are not NOR related. Bar = 1 μm. With permission, Skalníková et al. Physiol Res 56:797–806, 2007.