Figure 4.

mRNA expression of selected HS-modifying enzymes in non-fibrotic liver, fibrogenic diseases, and HCC tissues. (A,B) Relative expressions of the nine enzymes in the three sample groups (reference, eukaryotic 18S rRNA) are shown in arbitrary expression units (2^−ΔCt × 10⁶). Isozyme pairs are compared in A; enzymes with only a single investigated isoform are presented in B. Median expression differences and minimum and maximum expression values of the nine enzymes in the fibrotic and HCC groups relative to the median of the non-fibrotic group are shown in C. *, p<0.05; **, p<0.01; ***, p<0.001, Mann-Whitney U tests.