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MacroH2A1 is not required for DNA repair in vivo. Survival of 7-week-old H2afy-/- mice and littermate controls exposed to 6.5 Gy whole-body gamma irradiation. Four H2afy-/- (black circles) and six control mice were used (open circles). H2afy-deficient mice were not hypersensitive to DNA damage induced by ionizing irradiation, suggesting that macroH2A1 is not essential for DNA repair.
