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. 2010 May;24(5):1479–1488. doi: 10.1096/fj.09-144733

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© 2010 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Inhibition of type I IFN antiviral activity by VACV IFNα/βBP and its VARV and MPXV orthologues. Supernatants containing the indicated recombinant proteins were preincubated with 50 U of each type I IFN and subsequently added to HeLa cell monolayers. After a 16 h incubation, cells were infected with VSV, and cell viability was determined after 48 h. Controls of nontreated, uninfected (−VSV), and infected (+VSV) cells are at left, separated by a dashed line. Results are means ± sd of triplicate samples from one representative experiment.