Table 7. Multivariable meta-regression analysis for different variables as indicated and described in the Methods section.

Potential Explanation Factor Variable	Resection Rate	Exploration Rate	CR	PR	SD	PD	Toxicity	Morbidity	Mortality
Institution	16.7% (17.4%)	13.3% (15.0%)	30.2% (31.9%)	20.9% (16.7%)	27.2% (10.7%)	12.8% (24.9%)	34.8% (35.2%)	20.8% (14.3%)	22.5% (19.6%)
Study design	1.2% (2.9%)	0.6% (1.6%)	3.1% (1.0%)	10.7% (4.0%)	4.1% (1.8%)	3.6% (6.9%)	3.8% (4.6%)	8.7% (2.0%)	2.3% (1.6%)
Chemotherapy	2.1% (3.1%)	0.8% (1.6%)	0.6% (8.1%)	6.0% (7.2%)	1.6% (0.8%)	0.2% (0.4%)	10.4% (2.4%)	0.1% (0.5%)	3.1% (6.8%)
Mean year of study interval (decades)	2.0% (1.9%)	1.1% (0.2%)	0.2% (2.0%)	0.6% (6.7%)	2.3% (1.0%)	0.9% (7.0%)	2.2% (1.5%)	3.2% (2.0%)	10.4% (10.6%)
Mean patient age (5-y intervals)	1.1% (1.1%)	1.2% (0.6%)	2.7% (1.1%)	3.4% (3.4%)	1.5% (1.8%)	1.4% (1.7%)	3.5% (2.6%)	9.9% (4.1%)	9.9% (4.6%)
Response evaluation criteria			1.5% (3.4%)	2.7% (3.6%)	2.4% (0.1%)	2.6% (0.3%)
Resectability	14.0% (9.0%)	25.5% (10.5%)	1.0% (0.9%)	0.0% (2.6%)	4.1% (0.9%)	1.1% (8.1%)	0.3% (0.2%)	2.2% (4.9%)	0.6% (0.2%)
Resectability evaluation criteria	0.1% (0.7%)	1.4% (0.7%)

The fraction of explained variance is given in %. Values in parentheses represent the fraction of explained variance in % from univariable analysis.

CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease.