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. 2010 Apr 20;5(4):e10215. doi: 10.1371/journal.pone.0010215

Figure 7. Effect of epithelial cell-specific PPAR γ deletion on target gene expression in colonic mucosa.

Figure 7

Expression of PPAR γ targets Plin2 (ADRP), Fabp2 (FABP); and pro-inflammatory genes TNF-α, IL-6 and IL-1β in the colonic mucosa in VC- and VC+ mice at 0, 2 and 7 days after dextran sodium sulfate (DSS) challenge. Compared to VC- mice, VC+ mice show reduced expression of Plin2 (ADRP) at day 7 of DSS challenge and of Fabp2 (FABP) at earlier time points (days 0 and 2). Expression of pro-inflammatory genes TNF-α, IL-6 and IL-1β are increased in VC+ mice compared to VC- mice after DSS challenge. Statistical significance is indicated by asterisks (P<0.05).