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. 2010 Feb 11;59(5):1132–1142. doi: 10.2337/db09-1105

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© 2010 by the American Diabetes Association.

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FIG. 8. — Mitochondrial function and expression in adipose tissue from C57BL/6J and GSTA4-null (−/−) mice. Mitochondria were isolated from EWAT of 4- to 5-month-old mice maintained on a standard chow (lean) or high-fat (obese) diets. A: Mitochondrial oxygen consumption in lean and obese wild-type (+/+) and GSTA4-null (−/−) adipose. The mitochondrial protein concentrations were 0.22 (lean +/+), 0.23 (obese +/+), 0.20 (lean −/−), and 0.23 (obese −/−) mg/ml. B: Oxygen consumption rates for all four groups (n = 3). Statistics calculated using two-way ANOVA for each state with Holm-Sidak post hoc analysis. Variation due to loss of GSTA4 in state 2: P = 0.1; variation due to obesity in state 3: P = 0.03. C: Mitochondrial matrix superoxide production (n = 3). Statistics calculated using two-way ANOVA with Bonferroni post hoc analysis. Effect of obesity: P = 0.0009; effect of GSTA4: P = 0.0018. D: Quantitation of mitochondrial protein carbonylation in EWAT from lean wild-type and GSTA4-null mice (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001.