TABLE 3.

Association of HDL measures with incident type 2 diabetes

	Quintile 1	Quintile 2	Quintile 3	Quintile 4	Quintile 5	P for trend
HDL cholesterol (mg/dl)	≤39.8	39.9–46.3	46.4–52.8	52.9–61.8	>61.8
Model 1	9.52 (7.89–11.48)	5.32 (4.37–6.48)	2.94 (2.38–3.63)	1.84 (1.47–2.30)	Referent	<0.001
Model 2	4.01 (3.28–4.92)	3.14 (2.56–3.86)	2.05 (1.65–2.55)	1.54 (1.23–1.93)	Referent	<0.001
HDLNMR particle concentrations
Total HDLNMR (μmol/l)	≤29.0	29.1–31.9	32.0–34.3	34.4–37.3	>37.3
Model 1	1.60 (1.39–1.83)	1.21 (1.04–1.40)	1.07 (0.92–1.24)	1.01 (0.88–1.17)	Referent	<0.001
Model 2	1.20 (1.03–1.40)	1.07 (0.91–1.25)	0.91 (0.77–1.07)	0.88 (0.75–1.02)	Referent	0.008
Large HDLNMR (μmol/l)	≤4	4.1–5.8	5.9–7.7	7.8–10.0	>10.0
Model 1	9.89 (8.20–11.93)	5.36 (4.39–6.55)	3.31 (2.69–4.08)	1.84 (1.47–2.31)	Referent	<0.001
Model 2	4.51 (3.68–5.52)	3.19 (2.58–3.94)	2.54 (2.04–3.15)	1.72 (1.36–2.17)	Referent	<0.001
Medium HDLNMR (μmol/l)	≤0.2	0.3–1.4	1.5–3.0	3.1–5.6	>5.6
Model 1	Referent	1.19 (1.01–1.41)	1.23 (1.04–1.46)	1.20 (1.01–1.41)	1.11 (0.95–1.30)	0.47
Model 2	Referent	1.14 (0.96–1.35)	1.01 (0.84–1.20)	1.04 (0.87–1.23)	1.03 (0.87–1.21)	0.72
Small HDLNMR (μmol/l)	≤18.8	18.9–21.9	22.0–24.4	24.5–27.3	>27.3
Model 1	Referent	1.46 (1.20–1.77)	1.69 (1.40–2.04)	2.21 (1.85–2.65)	2.68 (2.25–3.18)	<0.001
Model 2	Referent	1.19 (0.97–1.45)	1.36 (1.12–1.65)	1.51 (1.25–1.81)	1.84 (1.54–2.19)	<0.001
HDLNMR average size (nm)	≤8.5	8.6–8.7	8.8–9.0	9.1–9.4	>9.4
Model 1	12.01 (9.31–15.50)	9.04 (6.95–11.75)	4.78 (3.67–6.23)	2.10 (1.59–2.79)	Referent	<0.001
Model 2	4.56 (3.50–5.93)	3.97 (3.03–5.21)	3.08 (2.35–4.03)	1.72 (1.29–2.29)	Referent	<0.001

Data are adjusted HR (95% CI) and (ranges minimum–maximum) and are given for each quintile. See Table 2 legend for model adjustments.